Research results of Professor O.E. Glukhova published in a highly rated journal

Molecules Magazine (Impact Factor: 3.060 (2018); 5-Year Impact Factor: 3.380 (2018), Q1) published the results of a scientific study by Professor O. E. Glukhova. In this paper, "Liposome Drug Delivery System across Endothelial Plasma Membrane: Role of Distance between Endothelial Cells and Blood Flow Rate", new patterns of targeted drug delivery using liposomes were obtained using in silico studies. The regularities of interaction of the liposome with the membrane of endothelial cells lining the inner surface of blood vessels, as well as the regularities of liposome penetration through the interendothelial slit space, were studied.
In silico modeling of liposome movement in the blood stream is implemented in accordance with the actual physical conditions of wall hemodynamics. The simulation results showed that liposomes can not only get stuck in the intercellular spaces under certain conditions, but also break down in a narrow intercellular space.
At the same time, it was found that the bilayer phospholipid membranes of liposomes exhibit greater elasticity. For example, the liposome shell is able to withstand volumetric deformation up to 15% with an increase in liposome energy by 26%. It was also found that liposomes moving in the wall layer of the bloodstream inevitably adhere to the membrane of endothelial cells. The adhesion of the liposome to the membrane is accompanied by its gradual fusion with the membrane bilayer of the cell membrane, which leads to the gradual release of the drug into the cell.
The obtained new knowledge reveals the mechanisms of penetration of liposomes with the drug into the cells, which is extremely important for further studies of the use of liposomes for targeted drug delivery, taking into account the characteristics of endothelial cells of various vessels.