The scientific team by Professor O.E. Glukhova became a part of the executors of the project, funded by the Ministry of Education and Science of the Russian Federation, on "Research and development of 3-D nanocomposite bioconstructions to ensure the life cycle of cellular material and the regeneration of biological tissues." The project is implemented on the basis of the NIU "MIET" within the framework of the FTP (agreement of September 29, 2016 No. 14.578.21.0221) in conjunction with the Moscow Regional Scientific Research Clinical Institute. M.F. Vladimirsky (MONIKI).
The essence of the project is to obtain 3-D bioconstructions by evaporation of a water-albumin solution with carbon nanotubes by means of continuous and pulsed femtosecond laser radiation. The biocomposites created on the basis of multilayer and single-walled nanotubes are completely overgrown with cells by fibroblasts for 72 hours. Samples based on both types of tubes do not have toxic effects on cells and do not change their normal structure. Thus, 3-D biostructures, nanostructured with pulsed and continuous laser radiation, can be used as implant materials for the restoration of connective tissues of a living organism.
The group by O.E. Glukhova reveal the conditions for the formation of a nanotube frame under the action of laser irradiation, the process of formation of 3-D bioconstructions based on the carcass and albumin, and the patterns of transformation of albumin and collagen proteins under laser heating using the modern quantum-mechanical and molecular-dynamic approaches.
In the Figures - Photographs of fibroblast cell colonies on 3-D bioconstructions with a single-walled carbon nanotube framework, and a computer simulation freeze frame for the formation of a nanotube frame under the action of a laser beam.